Hi @Luke76. I suffer from bipolar and anxiety and I had gastric bypass a little over a year ago. I was concerned as to whether or not my medications would continue to work for me post-op as good as they had for years prior. I take the same meds and the same doses that I did before surgery and I haven't had any problems. If anything, the weight loss has improved my mental health. For my two cents, if you have a good relationship with your doctor and are open and honest with how you're doing and what your needs are, you can work through any adjustments that may or may not be necessary post op. I wouldn't be surprised if your dosage stayed the same or even decreased after significant weight loss. One thing I was concerned about was absorption. I crush every pill that can be crushed to alleviate the absorption problem. The only pill I take that can't be crushed is my bupropion and I haven't had any issues with it. I wish you the best as you move forward in this. Let me know if you have any questions.